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교수 및 교실소개

이현승 프로필 사진
이름
이현승   이메일아이콘
전공
내과학
연락처
연구실
의생명융합연구센터 4층

최종학력

Mar. 2000 – Feb. 2006 Gachon Medical School (M.D.)
Mar. 2009 – Feb. 2011 Gachon University of Medicine and Science (M.S. Department of Medicine)
Feb. 2011 – Feb. 2015 Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (Ph.D.)

경 력

Mar. 2006 – Feb. 2007 Gachon University Gil Hospital [Internship]
Mar. 2007 – Feb. 2011 Gachon University Gil Hospital [Residentship of Internal Medicine]
2012-2015 Korea Advanced Institute of Science and Technology [Technical Research Personnel]
Mar. 2015 – Feb. 2017 Chungnam National University Hospital [Fellowship of Endocrinology and Metabolism]
Mar. 2017 – Feb. 2018 Chungnam National University Hospital [Clinical assistant professor of Endocrinology and Metabolism]
Mar. 2018 – Aug. 2018 Chungnam National University Hospital [Clinical associate professor of Endocrinology and Metabolism]
Sep. 2018 – Chungnam National University Hospital [Assistant professor of Endocrinology and Metabolism]

관심연구분야

내분비대사, 면역대사학(지방간, 근골격계)

논문

1. Hyon-Seung Yi, Young Sil Eom, Ie Byung Park, Sangho Lee, Suntaek Hong, Harald Jüppner, Michael Mannstadt, Sihoon Lee. Identification and characterization of C106R, a novel mutation in the DNA-binding domain of GCMB, in a family with autosomal dominant hypoparathyroidism. Clinical Endocrinology 2012 May;76(5):625-33.

2. Hyon-Seung Yi, Young-Sun Lee, Jin-Seok Byun, Wonhyo Seo, Jong-Min Jeong, Ogyi Park, Gregg Duester, Takeshi Haseba, Sun Chang Kim, Keun-Gyu Park, Bin Gao, and Won-Il Jeong. Alcohol Dehydrogenase III Exacerbates Liver Fibrosis by Enhancing Stellate Cell Activation and Suppressing Natural Killer Cells in Mice. Hepatology 2014 Sep;60(3):1044-53.

3. Young-Sun Lee, Hyuk Soo Eun, So Yeon Kim, Jong-Min Jeong, Wonhyo Seo, Jin-Seok Byun, Won-Il Jeong, Hyon-Seung Yi*. Hepatic immunophenotyping for streptozotocin-induced hyperglycemia in mice. Sci Rep. 2016 Jul 28;6:30656. (Corresponding author)

4. Seong Eun Lee, Seul Gi Kang, Min Jeong Choi, Saet-byel Jung, Min Jeong Ryu, Hyo Kyun Chung, Joon Young Chang, Yong Kyung Kim, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Heung Kyu Lee, Hyon-Seung Yi and Minho Shong. Growth Differentiation Factor 15 Mediates Systemic Glucose Regulatory Action of T Helper Type 2 Cytokines. Diabetes. 2017 Nov;66(11):2774-2788. (Co-corresponding author)

5. Hyo Kyun Chung, Jung Tae Kim, Hyeon-Woo Kim, Minjoo Kwon, So Yeon Kim, Minho Shong, Koon Soon Kim, Hyon-Seung Yi. GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury. Sci Rep. 2017 Dec 8;7(1):17238 (Corresponding author)

6. Hyon-Seung Yi, Joon Young Chang and Minho Shong. The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases. J Mol Endocrinol. 2018 Oct;61(3):R91-95

7. Hyon-Seung Yi, So Yeon Kim, Jung Tae Kim, Young-Sun Lee, Ji Sun Moon, Mingyo Kim, Yea Eun Kang, Kyong Hye Joung, Ju Hee Lee, Hyun Jin Kim, Kwangsik Chun, Minho Shong, Bon Jeong Ku. T cell senescence contributes to abnormal glucose homeostasis in humans and mice. Cell death and disease. 2019. In press (First author and Corresponding author)

수상경력

- 2006 Patriotism Award from Gachon Medical School

- 2007 Excellent Resident Award of Department of Internal Medicine in Gachon University Gil Hospital

- 2010 International Clinical Endocrinology Travel Grant Award

- 2011 6th ALPD/C in Fukuoka Travel Grant Award

- 2013 AASLD Distinction of Presidential Poster

- 2014 Student Merit Award (Research Society on Alcoholism)

- 2014 Young Investigator Award (Korean Society for Cell Biology)

- 2015 Best Poster Award (Korean Society for Cell Biology)

- 2015 Excellent Paper Award (KAIST, College of Biological Science)

- 2016 Plenary Oral Session Award (Korean Endocrine Society)

- 2017 Best Oral Presentation Award (Korean Endocrine Society)

- 2018 Young Investigator Award (Korean Endocrine Society)

- 2018 Best Poster Oral Presentation Award (Korean Endocrine Society)

- 2018 Certificate of commendation (Minister of Health and Welfare, Korea)

- 2019 3rd Young Leaders Camp Best oral presentation (Korean Society Bone and Mineral Research)

연구실소개

면역계의 활성화는 병원체를 제거하는데도 중요하지만 과도한 면역계의 활성은 체내 염증반응의 증가로 대사질환을 유발하는 중요한 요인이 되기도 합니다. 저는 최근 다양한 면역세포(T세포 및 호산구)들이 간세포내 포도당 및 지방 대사에 미치는 영향에 대하여 실험하고 있습니다. Ex vivo 실험은 perfusion을 통해 마우스에서 간세포를 분리하고 비장이나 림프절에서 Magnetic assisted cell sorting(MACS)를 통해 T세포를 분리하여 사용합니다. In vivo 실험은 주로 간을 적출하여 간내 면역세포를 FACS를 통해 분석하고 glucose tolerance test 및 혈청의 인슐린을 측정합니다. 또한 DEN을 이용한 간암 유발 동물모델에서 간세포내의 미토콘드리아의 새로운 역할을 발견하는 연구도 함께 진행하고 있습니다.